Search resultsXanthohumol metabolites in faeces of rats
Title
Xanthohumol metabolites in faeces of rats
Publication type
Journal Article
Year of Publication
2004
Authors
Journal
Phytochemistry
Volume
65
Issue
5
Pagination
561 - 570
Date published
2004
ISBN
00319422 (ISSN)
Keywords
analytic method, animal experiment, Animalia, Animals, article, biotransformation, body weight, Cannabaceae, Chalcones, Chromatography, High Pressure Liquid, controlled study, dose response, drug metabolite, drug structure, Faeces, Feces, feeding, Female, Flavanones, flavonoid, high performance liquid chromatography, HPLC-NMR, Humulus, Humulus lupulus, mass spectrometry, Metabolites, Molecular Structure, nonhuman, nuclear magnetic resonance spectroscopy, Nuclear Magnetic Resonance, Biomolecular, Propiophenones, rat, Rats, Rats, Sprague-Dawley, time, xanthohumol
Abstract
Xanthohumol (1), isolated from hop, was fed to rats in a dose of 1000 mg kg-1 body weight. The faeces of the animals were collected after 24 and 48 h and analysed for metabolites of 1. Approximately 89% of the recovered flavonoid-compounds consisted of unchanged 1. Sixteen metabolites and six previously known metabolites were isolated and characterized by coupling techniques (HPLC-NMR, HPLC-MS and HPLC-DAD). Their structures were elucidated by spectroscopic methods, especially using NMR spectroscopy. Twenty metabolites had a modified chalcone structure and two metabolites were flavanone derivatives.