Search resultsHippocampal neurogenesis in Alzheimer's disease: Is there a role for dietary modulation?
Title
Hippocampal neurogenesis in Alzheimer's disease: Is there a role for dietary modulation?
Publication type
Journal Article
Year of Publication
2014
Authors
Journal
Journal of Alzheimer's Disease
Volume
38
Issue
1
Pagination
11 - 38
Date published
2014
ISBN
13872877 (ISSN)
Keywords
alcohol, alcohol consumption, Alzheimer disease, Alzheimer's disease, bilobalide, blueberry, blueberry extract, caffeine, caloric restriction, calorie restriction, carbohydrate, clinical assessment, coffee, cognitive defect, curcumin, cyanocobalamin, dementia, diet, docosahexaenoic acid, drug bioavailability, fat, fatty acid, Fatty Acids, flavonoid, folate, folic acid, Ginkgo biloba, Ginkgo biloba extract, hippocampus, human, Humans, icosapentaenoic acid, ketogenic diet, lipid diet, motor dysfunction, nervous system development, neurogenesis, nonhuman, nutrients, omega 3 fatty acid, polyphenol, polyphenols, polyunsaturated fatty acid, priority journal, quercetin, resveratrol, review, saturated fatty acid, thiamine, vitamin supplementation, zinc
Abstract
Alterations in hippocampal neurogenesis have been recognized as an integral part of Alzheimer's disease. Adult hippocampal neurogenesis is regulated by intrinsic and extrinsic factors; one of them is diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis studies in Alzheimer's disease and focuses on the role of diet. The review highlights some of the key dietary compounds and interventions such as calorie restriction, fat, polyphenols, zinc, folate, alcohol and thiamine, and emphasizes the pathways that they modify.