Search resultsIs moderate red wine consumption safe in inactive inflammatory bowel disease?
Title
Is moderate red wine consumption safe in inactive inflammatory bowel disease?
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
Digestion
Volume
84
Issue
3
Pagination
238 - 244
Date published
2011
ISBN
00122823 (ISSN)
Keywords
Adult, alcohol consumption, article, blood sampling, C reactive protein, C-Reactive Protein, calgranulin, clinical article, Colitis, Ulcerative, controlled study, Crohn disease, Crohn's disease, disease activity, Feces, feces analysis, Female, human, Humans, inflammation, intestine mucosa permeability, Intestines, Lactulose, Leukocyte L1 Antigen Complex, male, Mannitol, Middle Aged, Permeability, priority journal, prospective study, questionnaire, Questionnaires, recurrent disease, red wine, Severity of Illness Index, Sucrose, sugar, symptom, ulcerative colitis, urinalysis, wine, Young Adult
Abstract
Background: Alcohol consumption is a potential trigger for inflammatory bowel disease (IBD) flare because of alcohol-induced oxidative stress and its deleterious effects on gut barrier function. Additionally, we have recently shown that alcohol consumption is associated with more symptoms in IBD. However, it is not known whether moderate daily alcohol consumption can modify IBD disease activity. To test what effects alcohol may have on patients with IBD, we evaluated the effect of moderate daily red wine for 1 week on two factors associated with recurrent IBD disease activity: intestinal permeability and stool calprotectin. Methods: To assess the effects of moderate daily alcohol consumption on intestinal permeability and inflammation, we recruited 21 patients: 8 with inactive ulcerative colitis (UC), 6 with inactive Crohn's disease (CD), and 7 healthy controls. All participants with IBD completed a validated questionnaire on disease activity (Crohn's disease activity index or ulcerative colitis clinical activity index), to confirm they had inactive disease. All subjects then underwent a baseline assessment that included a blood draw, urine collection after sugar challenge, and stool collection. Subjects then consumed 1-3 glasses of red wine a day for 1 week (approx. 0.4 g EtOH/kg), and repeated the three measures. Results: No subjects flared during the study. Moderate alcohol consumption did not significantly change either clinical disease activity scores or C-reactive protein. In contrast to healthy subjects, daily consumption of red wine significantly (1) decreased stool calprotectin in IBD subjects from baseline (p = 0.001) and (2) increased intestinal permeability as measured by urinary lactulose/mannitol excretion (marker of small bowel permeability) in CD (p = 0.028) or urinary sucralose secretion (marker of large bowel permeability) in UC (p = 0.012). Conclusions: One week of moderate consumption of red wine in inactive IBD was associated with a significant decrease in stool calprotectin and a significant increase in intestinal permeability. Our data suggests that patients with inactive IBD who drink red wine daily may be at an increased long-term risk for disease relapse.