Search resultsAlcohol consumption, bone density, and hip fracture among older adults: The cardiovascular health study
Title
Alcohol consumption, bone density, and hip fracture among older adults: The cardiovascular health study
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
Osteoporosis International
Volume
18
Issue
5
Pagination
593 - 602
Date published
2007
ISBN
0937941X (ISSN)
Keywords
abstinence, Aged, alcohol, alcohol consumption, article, beer, bone density, bone mineral density, cardiovascular function, cohort analysis, confidence interval, consumer, controlled study, dual energy X ray absorptiometry, epidemiology, Female, femur neck fracture, follow up, hip fracture, human, liquid, major clinical study, male, nutrition, population research, priority journal, risk assessment, sex difference, wine
Abstract
Introduction: Previous studies have found inconsistent relationships of alcohol consumption with risk of hip fracture, and the importance of bone mineral density and risk of falls in mediating such a relationship has not been determined. Methods: As part of the Cardiovascular Health Study, a population-based cohort study of adults aged 65 years and older from four U.S. communities, 5,865 participants reported their use of beer, wine, and liquor yearly. We identified cases of hip fracture unrelated to malignancy or motor vehicle accidents using hospitalization discharge diagnoses. A subgroup of 1,567 participants in two communities underwent dual-energy x-ray absorptiometry scans to assess bone mineral density. Results: A total of 412 cases of hip fracture occurred during an average of 12 years of follow-up. There was a significant U-shaped relationship between alcohol intake and risk of hip fracture (p quadratic 0.02). Compared with long-term abstainers, the adjusted hazard ratios for hip fracture were 0.78 (95% confidence interval [CI], 0.61-1.00) among consumers of up to 14 drinks per week and 1.18 (95% CI, 0.77-1.81) among consumers of 14 or more drinks per week. Alcohol intake was associated with bone mineral density of the total hip and femoral neck in a stepwise manner, with approximately 5% (95% CI, 1%-9%) higher bone density among consumers of 14 or more drinks per week than among abstainers. These relationships were all similar among men and women. Conclusions: Among older adults, moderate alcohol consumption has a U-shaped relationship with risk of hip fracture, but a graded positive relationship with bone mineral density at the hip.