Search resultsBeyond HDL-cholesterol increase: Phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers
Title
Beyond HDL-cholesterol increase: Phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
Journal of Lipid Research
Volume
48
Issue
7
Pagination
1550 - 1558
Date published
2007
ISBN
00222275 (ISSN)
Keywords
Adult, Aged, alcohol consumption, Alcohol Drinking, anthropometry, apolipoprotein, Apolipoprotein A-I, Apolipoprotein A-II, article, atherogenesis, beer, body mass, Body Mass Index, cholesterol blood level, Cholesterol, HDL, controlled study, correlation coefficient, Cross-Sectional Studies, Female, high density lipoprotein, high density lipoprotein 2, High density lipoprotein 3, high density lipoprotein cholesterol, human, human experiment, Humans, laboratory test, lipid analysis, lipid composition, lipoprotein blood level, low density lipoprotein, male, Middle Aged, Multivariate Analysis, normal human, nutritional status, phospholipid, phospholipid blood level, Phospholipids, physical activity, priority journal, qualitative analysis, triacylglycerol, Triglycerides, unclassified drug, very low density lipoprotein, wine
Abstract
The reduction of cardiovascular mortality associated with moderate alcohol consumption is chiefly thought to be mediated by an increase of high density lipoprotein cholesterol (HDL-CH). This study highlights additional qualitative changes of HDL that might augment this antiatherogenic effect. In 279 healthy men, alcohol and nutrient consumption were evaluated. Groups 1 (n = 62), 2 (n = 172), and 3 (n = 45) comprised subjects with alcohol consumption of 0-5.0, 5.1-30.0, and 30.1-75 g/day, respectively. Lipid analysis was performed in nonfractionated and fractionated plasma, including subfractions HDL 2a, HDL2b, and HDL3. No difference in LDL-cholesterol was observed. Compared with group 1, groups 2 and 3 exhibited significant increases of HDL-CH (group 1, 44 ± 10 mg/dl; group 2, 51 ± 11 mg/dl; group 3, 55 ± 11 mg/dl; mean ± SD, P < 0.0005), accompanied by enhanced lipidation of HDL (increase of the HDL 2-CH/HDL3-CH ratio). Moreover, phospholipid enrichment of HDL occurred in alcohol consumers, whereas the ratios between other HDL components remained constant. Multivariate analysis revealed alcohol to have the foremost statistical influence on changes of the HDL fraction, followed by body mass index and physical activity level. The increased lipidation of HDL found in alcohol consumers might augment the antiatherogenic effect of HDL-CH increase. In addition, the phospholipid enrichment of HDL might reduce the inflammatory response of atherogenesis. Copyright