Search resultsAssociation between different alcoholic beverages and leukoplakia among non- to moderate-drinking adults: A matched case-control study
Title
Association between different alcoholic beverages and leukoplakia among non- to moderate-drinking adults: A matched case-control study
Publication type
Journal Article
Year of Publication
2006
Authors
Journal
European Journal of Cancer
Volume
42
Issue
4
Pagination
521 - 527
Date published
2006
ISBN
09598049 (ISSN)
Keywords
Adult, Aged, alcohol, Alcohol Drinking, alcoholic beverage, Alcoholic Beverages, article, beer, Case-Control Studies, controlled study, disease association, drinking, Female, gender, human, Humans, leukoplakia, logistic regression analysis, major clinical study, male, Middle Aged, patient, polyphenol, priority journal, red wine, Regression Analysis, risk assessment, Risk Factors, smoking, spirits, statistical significance, wine
Abstract
While heavy drinking is a risk factor for oral leukoplakia, the effects of moderate drinking and of different alcoholic beverages are unclear and were investigated in this case-control study. 187 leukoplakia patients, aged 40-65 years, who were not heavy drinkers and did not change their drinking/smoking habits over the last decade, were age/gender matched to 187 controls. The effect of regular, moderate, overall alcohol, beer, wine, spirit drinking, adjusted for the effects of heavy smoking and other important co-variables, were assessed using conditional logistic regression analysis. Overall alcohol (OR, 0.22), wine (OR, 0.20), spirits (OR, 2.93) were significantly associated to leukoplakia. A statistically significant interaction wine/heavy smoking was also found. Such different effects could be explained by the ethanol antagonising potential of other drink components, such as polyphenols, abundant in red wine and scarce in spirits. Among heavy smokers, the preventive effect of wine was more than multiplicative.