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Title

Dietary factors and Alzheimer's disease

Publication type

Journal Article

Year of Publication

2004

Authors

Luchsinger, J.A., Mayeux, R.

Journal

Lancet Neurology

Volume

Issue

Pagination

579 - 587

Date published

2004

ISBN

14744422 (ISSN)

Keywords

alcohol, alcohol consumption, alpha tocopherol, Alzheimer disease, Animals, antioxidant activity, apolipoprotein E, apoptosis, ascorbic acid, brain atrophy, brain cortex, calcium transport, cardiovascular disease, carotene, chromosome 21, clinical trial, cognition, cohort analysis, cyanocobalamin, Depression, diet, diet supplementation, disease course, disease severity, environmental factor, fatty acid, fish, folic acid, gene mutation, genetic variability, head injury, high density lipoprotein, homocysteine, human, Humans, hydrogen peroxide, hyperinsulinemia, lipid metabolism, nerve cell degeneration, neurotoxin, nonhuman, nonsteroid antiinflammatory agent, Nutritional Requirements, onset age, oxidative stress, pathogenesis, prevalence, priority journal, protein blood level, protein function, pyridoxine, reactive oxygen metabolite, review, risk assessment, risk factor, Risk Factors, smoking habit, stroke, thrombocyte adhesion, wine

Abstract

Alzheimer's disease (AD) is increasing in prevalence, and environmental risk factors have not been identified with certainty. There is evidence that oxidative stress, homocysteine-related vitamins, fats, and alcohol have a role in the pathogenesis of AD. Few large epidemiological studies have explored the associations between nutrients and AD, and there has been only one trial of vitamin E in the prevention of AD. Some studies suggest that high intake of vitamins C, E, B6, and B12, and folate, unsaturated fatty acids, and fish are related to a low risk of AD, but reports are inconsistent. Modest to moderate alcohol intake, particularly wine, may be related to a low risk of AD. Available data do not permit definitive conclusions regarding diet and AD or specific recommendations on diet modification for the prevention of AD.

DOI

https://dx.doi.org/10.1016/S1474-4422(04)00878-6

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