Search resultsEffect of alcohol consumption on endothelial function in men with coronary artery disease
Title
Effect of alcohol consumption on endothelial function in men with coronary artery disease
Publication type
Journal Article
Year of Publication
2002
Authors
Journal
Atherosclerosis
Volume
165
Issue
1
Pagination
145 - 152
Date published
2002
ISBN
00219150 (ISSN)
Keywords
Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, Analysis of Variance, apolipoprotein C2, apolipoprotein C3, apolipoprotein E, artery diameter, article, Blood Chemical Analysis, brachial artery, Case-Control Studies, clinical trial, concentration (parameters), controlled clinical trial, controlled study, Coronary Angiography, coronary artery disease, Coronary Disease, coronary risk, disease association, drinking, echography, Endothelium, Endothelium, Vascular, glyceryl trinitrate, human, Humans, hyperemia, hyperuricemia, lipid analysis, major clinical study, male, Middle Aged, multiple regression, Multivariate Analysis, Nitroglycerin, priority journal, probability, Prospective Studies, Reference Values, Regional Blood Flow, Regression Analysis, risk factor, triacylglycerol, Ultrasonography, Doppler, vasodilatation, Vasodilation
Abstract
An inverse relationship between moderate alcohol consumption and coronary artery disease (CAD) has been observed in several epidemiologic studies. Whether improvement of endothelial function is involved in this beneficial effect is unknown. We investigated endothelial function of the brachial artery in 108 men with CAD, 54 of whom consumed alcohol on at least 1 day per week. Brachial artery diameter responses to hyperemic flow (FMD) and to administration of nitroglycerin (NTG) spray were measured using high-resolution ultrasonography. Coronary risk factors and hyperuricemia were present more frequently among drinkers, who also had higher concentrations of triglyceride and apolipoproteins C2, C3, and E. FMD was greater in drinkers (P<0.0001), while NTG-induced dilation was not. Multiple regression analysis showed alcohol consumption to be one of the factors favorably influencing FMD. These findings suggest that alcohol consumption may improve endothelial function in men with CAD.