Search resultsDeterminants of platelet aggregation in 50-70-year-old men from three Japanese communities
Title
Determinants of platelet aggregation in 50-70-year-old men from three Japanese communities
Publication type
Journal Article
Year of Publication
2002
Authors
Journal
Atherosclerosis
Volume
165
Issue
2
Pagination
327 - 334
Date published
2002
ISBN
00219150 (ISSN)
Keywords
adenosine diphosphate, Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, Arachidonic Acid, article, blood, body mass, Body Mass Index, cardiovascular disease, Cardiovascular Diseases, community care, controlled study, cross-sectional study, diet, dietary intake, drinking behavior, fatty acid, fatty acid blood level, Fatty Acids, gamma glutamyltransferase, geometry, human, Humans, ingestion, Japan, leukocyte count, Life Style, lifestyle, lipid composition, male, Middle Aged, N3-Polyunsaturated fatty acids, Platelet aggregation, polyunsaturated fatty acid, priority journal, Regional population, risk factor, Risk Factors, sea food, Seafood, smoking, soybean, thrombocyte aggregation, White blood cell counts
Abstract
To investigate the association of lifestyle and constitutional variables with platelet aggregation, we examined the platelet aggregation, serum fatty acid composition, alcohol intake, smoking, and dietary intake of seafood and soybean estimated by a 1-week dietary record in 448 males aged 50-70 in three rural Japanese communities: Ikawa, Akita prefecture (northeast coast), Noichi, Kochi prefecture (southwest coast), and Kyowa, Ibaraki prefecture (central inland). Platelet aggregatory threshold index (PATI) was used to determine the minimum concentration of adenosine 5′-diphosphate (ADP) that caused a non-reversible aggregation of platelets. Intake of seafood and n3-polyunsaturated fatty acid and ingestion of ethanol were higher in the northeast coastal community than in the other two communities. Mean platelet and white blood cell counts were lower in northeast coastal community than in the other two communities. The geometric mean PATI was higher (i.e. platelet aggregation was lower) in the northeast coastal community than the other two communities. Within the entire sample, platelet aggregation correlated inversely with serum level of n3-polyunsaturated fatty acids and γ-glutamyl transpeptidase, an index of alcohol consumption, and positively with platelet and white blood cell counts. Platelet aggregation tended to correlate positively with serum arachidonic acid. There was no correlation between smoking and platelet aggregation. Our results suggest that seafood intake and moderate alcohol consumption reduce platelet aggregation.