Search resultsEffects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of prostanoids
Title
Effects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of prostanoids
Publication type
Journal Article
Year of Publication
2000
Authors
Journal
Alcohol and Alcoholism
Volume
35
Issue
6
Pagination
594 - 600
Date published
2000
ISBN
07350414 (ISSN)
Keywords
11 oxothromboxane B2, 2,3 dinor 6 oxoprostaglandin F1 alpha, 2,3 dinorthromboxane B2, Adult, alcohol, alcohol consumption, Analysis of Variance, article, clinical trial, controlled clinical trial, controlled study, enzyme activity, Ethanol, hemostasis, human, human experiment, Humans, male, meal, Middle Aged, normal human, plasminogen activator inhibitor 1, Platelet aggregation, Postprandial Period, priority journal, prostacyclin, Prostaglandins, prostanoid, randomized controlled trial, shear stress, thrombocyte aggregation, thromboxane A2, triacylglycerol, triacylglycerol blood level, Triglycerides, urinary excretion, Von Willebrand factor, wine
Abstract
Moderate regular alcohol intake has been found to be associated with a decreased risk for coronary heart disease and stroke. We investigated the effects of acute intake of red wine (60 g ethanol) and a standard dinner under controlled conditions on haemostatic factors. Shear-induced platelet aggregation (SIPA) decreased after the intake of alcohol irrespective of whether the subjects were fasting or not, and also after the intake of food. The intake of alcohol inhibited the postprandial increase of yon Willebrand factor multimers. Plasma levels of plasminogen activator inhibitor 1 activity (PAI-1) and serum triglycerides were increased by alcohol. Excretion of the platelet thromboxane A2 metabolites 11-dehydrothromboxane B2 and 2,3-dinorthromboxane B2, as well as the endothelial prostacyclin metabolite 2,3-dinor-6-ketoprostaglandin F(1α), into urine was not influenced by either alcohol or food. We conclude that eating a dinner together with red wine has no untoward effect on SIPA and that the decrease of SIPA is not specific for alcohol.