A meta-analysis of alcohol intake and risk of bladder cancer

Title
A meta-analysis of alcohol intake and risk of bladder cancer
Publication type
Journal Article
Year of Publication
2010
Journal
Cancer Causes and Control
Volume
21
Issue
11
Pagination
1843 - 1850
Date published
2010
ISBN
09575243 (ISSN)
Abstract

Objective: Epidemiologic studies have reported conflicting results relating alcohol intake to bladder cancer risk. A meta-analysis of cohort and case-control studies was conducted to pool the risk estimates of the association between alcohol intake and bladder cancer. Methods: Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary risk estimates. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for a series of exposure levels. Results: Nineteen studies met the inclusion criteria of the meta-analysis. No association with bladder cancer was observed in either overall alcohol intake group (OR = 1.00, 95% CI 0.89-1.10) or subgroups stratified by sex, study design, geographical region, or smoking status. However, in the analysis by specific beverages, both beer (OR = 0.86, 95% CI 0.76-0.96) and wine (OR = 0.85, 95% CI 0.71-1.00) consumption exhibited a negative dose-response relationship with bladder cancer. Conclusion: The overall current literature on alcohol consumption and the risk of bladder cancer suggested no association, while the consumption of beer and wine was associated with reduced risk of bladder cancer. Further efforts should be made to confirm these findings and clarify the underlying biological mechanisms.