Relation between alcohol consumption and arterial stiffness: A cross-sectional study of middle-aged Japanese women and men

Epidemiological data indicate the existence of a J-shaped association between alcohol consumption and cardiovascular mobility and mortality. However, studies assessing the relationship between alcohol consumption and pulse wave velocity (PWV) as a marker of arterial stiffness have provided inconsistent results. In addition, data regarding the effect of alcohol on arterial stiffness in women has been limited. This study aimed to clarify the relationship between alcohol consumption and PWV among female and male workers in Japan. Study participants were local government employees in Hokkaido, Japan, who underwent annual health check-ups. All data were collected using self-administered questionnaires. The average daily alcohol consumption of the previous month, based on the alcohol concentration of each beverage type (g/day, ethanol equivalent), was estimated according to the frequency and amount of consumption. Data from 3893 participants (812 women and 3081 men) were analyzed. In women, non-drinkers had significantly higher PWV than women who consumed <10g/day of alcohol. In men, compared with those who reportedly drank 20-39g/day, non-drinkers and those who drank <20g/day and ≥60g/day had significantly higher PWV. Alcohol consumption showed a J-shaped association with PWV in men (p for quadratic term<0.036) and marginally in women (p<0.056). The results of stratified analyses by age groups showed a significant J-shaped association, which was most notable for men ≥45 years (p<0.005). In middle-aged Japanese women and men, light-to-moderate alcohol consumption is associated with lower PWV, which in turn correlates with a reduction in vascular stiffness.