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The role of ethanol in pathogenesis of pancreatitis

Title
The role of ethanol in pathogenesis of pancreatitis
Publication type
Journal Article
Year of Publication
2011
Authors
Jelski, W., KutyŁowska, E., Szmitkowski, M.
Journal
Polski Merkuriusz Lekarski
Volume
30
Issue
175
Pagination
66 - 68
Date published
2011
ISBN
14269686 (ISSN)
Keywords
acetaldehyde, alcohol, alcohol dehydrogenase, alcoholic pancreatitis, Animal, Animals, Ethanol, Fatty acid ethyl esters, human, Humans, metabolism, oxidation reduction reaction, Oxidation-Reduction, oxidative stress, Pancreatitis, Pancreatitis, Alcoholic, review
Abstract
Alcohol consumption is associated with pancreatitis, but the mechanism unducing this injury is not fully understood. The pancreas can metabolize ethanol via oxidative pathway involving alcohol dehydrogenase (ADH), cytochrome P-450 2E1 and the nonoxidative pathway. Injury to the pancreas due to its capacity to metabolize ethanol may be mediated by direct effects of both fatty acid ethyl esters (FAEEs) and acetaldehyde and by alterations induced within the cells during ethanol metabolism, such as changes in the intracellular redox state and the generation of oxidative stress. These processes induce changes in pancreatic digestive enzymes secretion, what contributes to development of pancreatitis.
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