Effects of lifestyle-related factors on ischemic heart disease according to body mass index and fasting blood glucose levels in Korean adults

Objective To investigate the effects of lifestyle-related factors on ischemic heart disease (IHD) according to body mass index (BMI) and fasting blood glucose (FBG) levels among Korean adults. Methods A total of 119,929 men and 89,669 women (from National Sample Cohort version 2.0, National Health Insurance Service) aged 20 years who were examined during 2003–2006 and had no preexisting type 2 diabetes or circulatory diseases were followed until December 2015 to confirm IHD incident cases. Data on lifestyle-related factors (BMI, FBG, diet, smoking, alcohol consumption, and physical activity) were collected at baseline. Lifestyle-related risk factors were defined as mainly vegetable/mainly meat diet, former/current smoking, alcohol consumption 3 times/week, and no physical activity. Associations between these factors and IHD were examined using Cox proportional hazards regression models. Results High BMI (25 kg/m 2 ), high FBG (100 mg/dL), mainly meat diet, and former/current smoking were associated with increased risk for IHD. Alcohol consumption twice/week and physical activity twice/week were associated with lower risk of IHD. With increased lifestyle-related risk factors, the risk of IHD also increased in women (hazard ratio [HR] = 3.21, 95% confidence interval [CI] 2.18–4.73) and men (HR = 1.66, 95% CI 1.48–1.85). This increase was larger in women, with a significant sex interaction (p = 0.0001). Significant interactions between BMI and alcohol consumption (p = 0.0002) and between BMI and physical activity (p = 0.0063) were observed. Interactions were seen between FBG level and meal type in both BMI<25 kg/m 2 (p = 0.0106) and BMI25 kg/m 2 (p = 0.0281) and between FBG level and alcohol consumption in BMI 25 kg/m 2 (p = 0.0118). Conclusions The impact of lifestyle-related factors on IHD was more pronounced in women than in men and may be modified by BMI and FBG level among Korean adults. This might be taken into account when planning individual interventions to reduce IHD risk.