Molecular mechanism of alcohol-associated gastric cancer

Gastric cancer is the second most common cancer in China. Alcohol consumption is related to gastric cancer as a significant risk factor. Some key enzymes is expected to influence the alcohol-associated metabolism. There are many molecular mechanisms of alcohol-related gastric cancer, such as generation of acetaldehyde by microbiome, inflammation, up-regulation of Pol M genes, carcinogen-DNA adduct formation and genetic polymorphisms of alcohol metabolizing enzymes. Different types and concentrations of alcohol have different effects on the development of gastric cancer. This review presents a systematic exposition on the molecular mechanism of alcohol-associated gastric cancer.