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Title

Impact of alcohol and coffee intake on the risk of advanced liver fibrosis: A longitudinal analysis in HIV-HCV coinfected patients (ANRS HEPAVIH CO-13 cohort)

Publication type

Journal Article

Year of Publication

2018

Authors

Yaya, I., Marcellin, F., Costa, M., Morlat, P., Protopopescu, C., Pialoux, G., Santos, M.E., Wittkop, L., Esterle, L., Gervais, A., Sogni, P., Salmon-Ceron, D., Carrieri, M.P., Salmon, D., Dabis, F., Wittkop, L., Esterle, L., Sogni, P., Trimoulet, P., Izopet, J., Serfaty, L., Paradis, V., Spire, B., Carrieri, P., Valantin, M.A., Pialoux, G., Chas, J., Poizot-Martin, I., Barange, K., Naqvi, A., Rosenthal, E., Bicart-See, A., Bouchaud, O., Gervais, A., Lascoux-Combe, C., Goujard, C., Lacombe, K., Duvivier, C., Vittecoq, D., Neau, D., Morlat, P., Bani-Sadr, F., Meyer, L., Boufassa, F., Dominguez, S., Autran, B., Roque, A.M., Solas, C., Fontaine, H., Costagliola, D., Piroth, L., Simon, A., Zucman, D., Boué, F., Miailhes, P., Billaud, E., Aumaître, H., Rey, D., Couffin-Cadiergues, S., Marchand, L., Alagna, L., Terris, B., Krivine, A., Katlama, C., Valantin, M.A., Stitou, H., Benhamou, Y., Charlotte, F., Fourati, S., Simon, A., Cacoub, P., Nafissa, S., Poizot-Martin, I., Zaegel, O., Porcher, M., Tamalet, C., Pialoux, G., Chas, J., Slama, L., Callard, P., Bendjaballah, F., Le Pendeven, C., Marchou, B., Alric, L., Barange, K., Metivier, S., Selves, J., Larroquette, F., Rosenthal, E., Naqvi, A., Haudebourg, J., Saint-Paul, M.C., Partouche, C., Bouchaud, O., Ziol, M., Baazia, Y., Uzan, M., Bicart-See, A., Garipuy, D., Ferro-Collados, M.J., Selves, J., Nicot, F., Gervais, A., Yazdanpanah, Y., Adle-Biassette, H., Alexandre, G., Lascoux-Combe, C., Molina, J.M., Bertheau, P., Duclos, J., Palmer, P., Lacombe, K., Campa, P., Girard, P.M., Wendum, D., Cervera, P., Adam, J., Viala, C., Goujard, C., Teicher, E., Pallier, C., Vittecoq, D., Lortholary, O., Duvivier, C., Rouzaud, C., Lourenco, J., Touam, F., Louisin, C., Mélard, A., Neau, D., Ochoa, A., Blanchard, E., Castet-Lafarie, S., Cazanave, C., Malvy, D., Dupon, M., Dutronc, H., Dauchy, F., Lacaze-Buzy, L., Bioulac-Sage, P., Trimoulet, P., Reigadas, S., Morlat, P., Lacoste, D., Bonnet, F., Bernard, N., Bonarek Hessamfar, M., Roger-Schmeltz, J., Gellie, P., Thibaut, P., Paccalin, F., Martell, C., Carmen Pertusa, M., Vandenhende, M., Mercier, P., Malvy, D., Pistone, T., Receveur, M.C., Caldato, S., Bioulac-Sage, P., Trimoulet, P., Reigadas, S., Pellegrin, J.L., Viallard, J.F., Lazzaro, E., Greib, C., Bioulac-Sage, P., Trimoulet, P., Reigadas, S., Zucman, D., Majerholc, C., Guitard, F., Boué, F., Polo Devoto, J., Kansau, I., Chambrin, V., Pignon, C., Berroukeche, L., Fior, R., Martinez, V., Deback, C., Lévy, Y., Dominguez, S., Lelièvre, J.D., Lascaux, A.S., Melica, G., Billaud, E., Raffi, F., Alavena, C., Rodallec, A., Miailhes, P., Peyramond, D., Chidiac, C., Ader, F., Biron, F., Boibieux, A., Cotte, L., Ferry, T., Perpoint, T., Koffi, J., Zoulim, F., Bailly, F., Lack, P., Maynard, M., Radenne, S., Amiri, M., Le-Thi, T.T., Piroth, L., Duong Van Huyen, P.C.M., Buisson, M., Waldner-Combernoux, A., Mahy, S., Binois, R., Simonet-Lann, A.L., Croisier-Bertin, D., Aumaître, H., Bani-Sadr, F., Lambert, D., Nguen, Y., Rouger, C., Berger, J.L., Rey, D., Partisani, M., Batard, M.L., Cheneau, C., Priester, M., Bernard-Henry, C., de Mautort, E., Gantner, P., Fafi-Kremer, S., ANRS CO13-HEPAVIH Cohort Study Group

Journal

Nutrients

Volume

Issue

Date published

2018

Keywords

alcohol consumption, coffee, Cohort, HIV-HCV co-infection, liver fibrosis

Abstract

Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Methods: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. Results: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12-0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03-0.64) in high-risk alcohol drinkers and 0.11 (0.05-0.25) in low-risk alcohol drinkers). Conclusions: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.

DOI

https://dx.doi.org/10.3390/nu10060705

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