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Title

Association between alcohol consumption and multiple sclerosis: a meta-analysis of observational studies

Publication type

Journal Article

Year of Publication

2015

Authors

Zhu, T., Ye, X., Zhang, T., Lin, Z., Shi, W., Wei, X., Liu, Y., He, J.

Journal

Neurological Sciences

Volume

Issue

Pagination

1543 - 1550

Date published

2015

ISBN

15901874 (ISSN)

Keywords

alcohol, alcohol consumption, cohort analysis, disease association, human, meta analysis, meta-analysis, multiple sclerosis, observational study, population based case control study, prospective study, retrospective study, review, risk factor, sensitivity analysis, systematic review

Abstract

To investigate the association between alcohol consumption and multiple sclerosis risk, we performed a systematic literature search of PubMed, EmBase and Web of Science databases for all relevant articles regarding alcohol and multiple sclerosis. Our meta-analysis consisted of 10 studies, including nine case–controls and one cohort study. The odds ratios (OR) of the association between alcohol consumption and multiple sclerosis were 0.92 [95 % confidence interval (CI) 0.73–1.17] overall, 0.91 (95 % CI 0.39–2.41) for prospective study, and 0.92 (95 % CI 0.72–1.19) for retrospective studies. In addition, neither subgroup analyses nor sensitivity analyses showed a substantially change in the pooled OR and 95 % CI. Meta-analysis showed that there is no evidence that alcohol consumption is associated with an increased risk of multiple sclerosis. There may be a potential protective effect of alcohol consumption on MS incidence, however, this trend may not be obvious and should be validated by further research.

DOI

https://dx.doi.org/10.1007/s10072-015-2326-7

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