Search resultsTestosterone increases in men after a low dose of alcohol
Title
Testosterone increases in men after a low dose of alcohol
Publication type
Journal Article
Year of Publication
2003
Authors
Journal
Alcoholism: Clinical and Experimental Research
Volume
27
Issue
4
Pagination
682 - 685
Date published
2003
ISBN
01456008 (ISSN)
Keywords
4 methylpyrazole, 4-Methylpyrazole, Adult, alcohol, alcohol consumption, alcohol intoxication, alcohol metabolism, alcohol withdrawal, androgen, androstenedione, article, clinical trial, controlled clinical trial, controlled study, Cross-Over Studies, double blind procedure, Double-Blind Method, drug effect, drug inhibition, Ethanol, human, Humans, male, normal human, priority journal, Pyrazoles, randomization, randomized controlled trial, statistical analysis, testosterone, testosterone blood level
Abstract
Background: Heavy acute alcohol drinking decreases blood testosterone in men due to an effect on the testicular level. An acute increase in blood testosterone levels after a low alcohol dose has, however, recently been reported in women. The objective of this investigation was to study the effect of a low alcohol dose on testosterone in men and further elucidate the mechanism behind the effect by using 4-methylpyrazole, an inhibitor of alcohol metabolism. Methods: A double-blind placebo-controlled interventional crossover trial in random order (n = 13). Results: After intake of alcohol (0.5 g/kg, 10% w/v), an acute increase in plasma testosterone (from 13.5 ± 1.2 nmol/liter to 16.0 ± 1.6 nmol/liter, mean ± SEM; p < 0.05), a decrease in androstenedione (from 5.1 ± 0.4 nmol/liter to 4.0 ± 0.3 nmol/liter; p < 0.05), and an increase in the testosterone:androstenedione ratio (from 2.8 ± 0.3 to 4.2 ± 0.4; p < 0.01) were observed. The effects were not observed during pretreatment with 4-methylpyrazole (10-15 mg/kg orally), which inhibited the ethanol elimination rate by 37 ± 3%. Conclusions: Alcohol intake affects the androgen balance in men through an effect mediated by the alcohol-induced change in the redox state in the liver.