Search resultsModerate alcohol intake and renal function decline in women: A prospective study
Title
Moderate alcohol intake and renal function decline in women: A prospective study
Publication type
Journal Article
Year of Publication
2003
Authors
Journal
Nephrology Dialysis Transplantation
Volume
18
Issue
8
Pagination
1549 - 1554
Date published
2003
ISBN
09310509 (ISSN)
Keywords
Adult, alcohol, alcohol consumption, Alcohol Drinking, article, blood sampling, controlled study, creatinine, creatinine blood level, creatinine clearance, Female, follow up, Glomerular Filtration Rate, glomerulus filtration rate, human, Humans, hypertension, Kidney, kidney disease, kidney function, Middle Aged, nurse, Odds Ratio, prevalence, priority journal, Prospective Studies, prospective study, public health, questionnaire, Renal function, Renal Insufficiency, statistical analysis
Abstract
Background. The impact of moderate alcohol consumption on renal function has important public health implications given the high prevalence of alcohol use. Experimentally, alcohol may adversely affect renal function, but clinical data are limited and no large, prospective studies have examined this issue. Methods. In a prospective study of 1658 nurses enrolled in the Nurses' Health Study, we sought to determine if there was an association between moderate alcohol consumption and rate of decline in renal function. Daily alcohol intake was measured in 1990, 1994 and 1998 using a detailed questionnaire. Maximum daily alcohol intake was measured in 1988. Creatinine, measured from blood samples provided in 1989 and 2000, was used to estimate glomerular filtration rate (GFR) and creatinine clearance (CCr). Results. Compared to individuals with no alcohol intake, the odds ratios (ORs) for developing a ≥25% estimated GFR decline were: 0.98 (95% CI: 0.72-1.32) for 0.1-4.9 g/day, 0.83 (95% CI: 0.56-1.21) for 5-14.9 g/day and 0.81 (95% CI: 0.50-1.31) for 15-59.9 g/day. For women with hypertension (n=726), the ORs for a ≥25% estimated GFR decline were: 0.98 (95% CI: 0.53-1.21) for 0.1-4.9 g/day, 0.62 (95% CI: 0.34-1.12) for 5-14.9 g/day and 0.53 (95% CI: 0.25-1.12) for 15-59.9 g/day. Conclusions. Moderate alcohol consumption had no substantial adverse effect on renal function in women over an 11 year follow-up period.