Search resultsDoes caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?
Title
Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?
Publication type
Journal Article
Year of Publication
2003
Authors
Journal
Human Reproduction
Volume
18
Issue
12
Pagination
2704 - 2710
Date published
2003
ISBN
02681161 (ISSN)
Keywords
Abortion, Spontaneous, Adult, alcohol consumption, Alcohol Drinking, alcoholic beverage, article, birth, caffeine, case control study, Case-Control Studies, coffee, cohort analysis, Cohort Studies, confidence interval, controlled study, dietary intake, disease association, Epidemology, Ethanol, Female, follow up, high risk patient, human, Humans, Logistic Models, logistic regression analysis, major clinical study, maternal care, Odds Ratio, population research, Preconception Care, prediction, Pregnancy, Prospective Studies, prospective study, risk factor, Risk Factors, self report, spontaneous abortion, tea
Abstract
Background: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. Methods: We performed a nested case-control study using prospective data from a population-based cohort comprising 11 088 women aged 20-29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow-up [mean time: 2.1 years (range: 1.6-3.4)] were selected. Associations between self-reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. Results: Compared with women with a pre-pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77-2.06), 1.45 (0.87-2.41), 1.44 (0.87-2.37) and 1.72 (1.00-2.96) for a pre-pregnancy intake on 75-300, 301-500, 501-900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre-pregnancy intake of alcohol was not a predictor for spontaneous abortion. Conclusions: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low-to-moderate alcohol intake does not influence the risk.