Search resultsRelationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin
Title
Relationship between a wide range of alcohol consumptions, components of the insulin-like growth factor system and adiponectin
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
European Journal of Clinical Nutrition
Volume
61
Issue
2
Pagination
221 - 225
Date published
2007
ISBN
09543007 (ISSN)
Keywords
Acute Disease, adiponectin, Adult, Aged, alcohol consumption, Alcohol Drinking, article, blood level, Chronic Disease, controlled study, Cross-Sectional Studies, Dose-Response Relationship, Drug, Female, hospital patient, human, Humans, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Italy, Kruskal Wallis test, major clinical study, Middle Aged, somatomedin, somatomedin B, somatomedin binding protein 1, somatomedin binding protein 3, Somatomedins, Statistics, Nonparametric, women's health
Abstract
Objective: To explore the relation between a wide range of alcohol consumptions and levels of the components of insulin-like growth factor system (IGFs) and adiponectin in humans. Design: A cross-sectional study using controls from a case-control study on ovarian and endometrial cancer. Settings: The study included women hospitalized between 1999 and 2002 in Pordenone, Italy. Subjects: One hundred and eight cancer-free (controls) with a median age of 61 years (range 29-79 years), admitted for acute conditions unrelated to gynecologic, hormonal or metabolic disorders or diseases leading to dietary modifications. Interventions: Levels of IGF-I (total and free),total IGF-II, IGF-binding protein 1 (IGFBP-1), IGFBP-3 and adiponectin were individually measured, and their distributions across strata of alcohol consumption were tested by the Kruskal-Wallis statistic. Results: Median concentrations of total IGF-I were higher (P<0.01) in women reporting low (151ng/ml) or no alcohol consumption (134 ng/ml) compared to drinkers of 12-23 g/day (103 ng/ml) or ≤ 24 g/day (118 ng/ml). Median concentrations were higher (P=0.05) for IGFBP-3 in non-drinkers (2333 ng/ml) and in light drinkers (2647 ng/ml) compared to drinkers of ≤24 g/day (2090 ng/ml). No statistically significant difference emerged for other IGFs across levels of alcohol intakes. Adiponectin was slightly lower for non-drinkers, compared to all drinkers categories. Conclusions: Our study suggests that alcohol consumption is related to circulating levels of components of the IGF system and adiponectin. These results may have a potential impact on the prevention of several chronic diseases.