Search resultsThe effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: A human intervention study
Title
The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: A human intervention study
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
Diabetologia
Volume
50
Issue
7
Pagination
1388 - 1392
Date published
2007
ISBN
0012186X (ISSN)
Keywords
adiponectin, Adolescent, Adult, aerobic metabolism, alcohol consumption, Alcohol Drinking, article, blood sampling, body mass, body weight, citrate synthase, clinical article, clinical trial, controlled clinical trial, controlled study, Cross-Over Studies, crossover procedure, cytochrome c oxidase, diabetes mellitus, enoyl coenzyme A hydratase, enzyme activity, Female, fluid intake, High molecular weight adiponectin, human, human tissue, Humans, insulin, insulin sensitivity, Intramyocellular triacylglycerols, lean body weight, male, Moderate alcohol consumption, molecular weight, muscle biopsy, muscle metabolism, Muscle oxidative capacity, Muscles, obesity, oligomer, Overweight, oxygen, priority journal, protein blood level, quality of life, randomized controlled trial, Time Factors, whiskey
Abstract
Aims/hypothesis: The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity. Materials and methods: Eleven lean (BMI 18-25 kg/m2) and eight overweight (BMI ≥27 kg/m2) men consumed 100 ml whisky (∼32 g alcohol) or water daily for 4 weeks in a randomised, controlled, crossover trial. After each treatment period, muscle biopsies and fasting blood samples were collected. Results: Adiponectin concentrations increased (p<0.001) by 12.5% after 4 weeks of moderate alcohol consumption. Moderate alcohol consumption tended to increase HMW adiponectin by 57% (p=0.07) and medium molecular weight adiponectin by 12.5% (p=0.07), but not low molecular weight (LMW) adiponectin. Skeletal muscle citrate synthase, cytochrome c oxidase and β-3-hydroxyacyl coenzyme A dehydrogenase (β-HAD) activity were not changed after moderate alcohol consumption, but an interaction between alcohol consumption and BMI was observed for cytochrome c oxidase (p=0.072) and citrate synthase (p=0.102) activity. Among lean men, moderate alcohol consumption tended to increase cytochrome c oxidase (p=0.08) and citrate synthase activity (p=0.12) by 23 and 26%, respectively, but not among overweight men. In particular, plasma HMW adiponectin correlated positively with activities of skeletal muscle citrate synthase (r=0.64, p=0.009), cytochrome c oxidase (p=0.59, p=0.009) and β-HAD (r=0.46, p=0.056), while such correlation was not present for LMW adiponectin. Whole-body insulin sensitivity and intramyocellular triacylglycerol content were not affected by moderate alcohol consumption. Conclusions/interpretation: Moderate alcohol consumption increases adiponectin concentrations, and in particular HMW adiponectin. Concentrations of HMW adiponectin in particular were positively associated with skeletal muscle oxidative capacity.