Search resultsLife style habits such as alcohol consumption and physical activity in relation to serum apoB/apoA-I ratio amongst 64-year-old women with varying degrees of glucose tolerance
Title
Life style habits such as alcohol consumption and physical activity in relation to serum apoB/apoA-I ratio amongst 64-year-old women with varying degrees of glucose tolerance
Publication type
Journal Article
Year of Publication
2007
Authors
Journal
Journal of Internal Medicine
Volume
262
Issue
5
Pagination
537 - 544
Date published
2007
ISBN
09546820 (ISSN)
Keywords
Adult, alcohol, alcohol consumption, Alcohol Drinking, antilipemic agent, Apolipoprotein A-I, apolipoprotein A1, apolipoprotein B, Apolipoproteins, Apolipoproteins B, article, clinical assessment, cohort analysis, Cohort Studies, controlled study, Cross-Sectional Studies, cross-sectional study, diabetes mellitus, Diabetes Mellitus, Type 2, Educational Status, estrogen, Exercise, Female, fibric acid derivative, gestagen, glucose intolerance, glucose tolerance, Hormone Replacement Therapy, hormone substitution, human, Humans, hydroxymethylglutaryl coenzyme A reductase inhibitor, impaired glucose tolerance, laboratory, Life Style, lifestyle, major clinical study, Middle Aged, obesity, observational study, physical activity, postmenopause, priority journal, protein blood level, questionnaire, sweating, Type 2 diabetes, university hospital, wine
Abstract
Objectives. To investigate how life style factors such as alcohol consumption and physical activity relate to the serum apoB/apoA-I ratio in a cohort of middle-aged women with varying degrees of glucose tolerance. Design. Observational, cross-sectional cohort study. Setting. Research laboratory at a University Hospital. Subjects. A screened cohort of 64-year-old postmenopausal women with varying degrees of glucose tolerance, ranging from diabetes (n = 232), impaired (n = 212) and normal (n = 191) glucose tolerance. Main outcome measure. ApoB/apoA-I ratio in relation to alcohol consumption and physical activity as assessed by questionnaires. Results. Alcohol consumption and regular physical activity at high levels were inversely associated with the serum apoB/apoA-I ratio independently of confounding factors such as obesity, lipid-lowering treatment, degree of glucose tolerance and hormone replacement therapy. Alcohol seemed related to the apoB/apoA-I ratio mainly through increasing apoA-I, whereas physical activity seemed mainly related to lowering of apoB. Alcohol consumption above a daily intake of 8.9 g, i.e. less than a glass of wine was accompanied by a decrease in apoB/apoA-I ratio. Conclusions. Amongst these 64-year-old women with varying degrees of glucose tolerance, a moderate alcohol intake and regular physical exercise leading to sweating were associated with lower apoB/apoA-I ratio and these effects seem to be additive.