Search resultsEthanol for cardiac ischemia: The role of protein kinase c
Title
Ethanol for cardiac ischemia: The role of protein kinase c
Publication type
Journal Article
Year of Publication
2008
Authors
Journal
Therapeutic Advances in Cardiovascular Disease
Volume
2
Issue
6
Pagination
469 - 483
Date published
2008
ISBN
17539447 (ISSN)
Keywords
alcohol, alcohol consumption, alcohol derivative, alcohol tolerance, Animals, antioxidant activity, Cardiac protection, Central Nervous System Depressants, coronary artery blood flow, drug megadose, endothelial dysfunction, enzyme activity, Ethanol, evidence based practice, heart muscle ischemia, heart protection, human, Humans, inhalation anesthetic agent, Ischemia, Ischemic Preconditioning, Ischemic Preconditioning, Myocardial, isoenzyme, mortality, Myocardial Ischemia, nitric oxide synthase, nonhuman, PKC, priority journal, protein expression, protein function, protein kinase C, protein kinase C activator, protein kinase C inhibitor, protein targeting, Reperfusion, reperfusion injury, review, risk reduction, signal transduction
Abstract
The physiological effects of ethanol are dependent upon the amount and duration of consumption. Chronic excessive consumption can lead to diseases such as liver cirrhosis, and cardiac arrhythmias, while chronic moderate consumption can have therapeutic effects on the cardiovascular system. Recently, it has also been observed that acute administration of ethanol to animals prior to an ischemic event provides significant protection to the heart. This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent.