Search resultsModerate alcohol consumption and diseases of the gastrointestinal system: A review of pathophysiological processes
Title
Moderate alcohol consumption and diseases of the gastrointestinal system: A review of pathophysiological processes
Publication type
Journal Article
Year of Publication
2005
Authors
Journal
Digestive Diseases
Volume
23
Issue
3-4
Pagination
177 - 180
Date published
2005
ISBN
02572753 (ISSN)
Keywords
acetaldehyde, Adult, age distribution, Aged, albumin, alcohol, alcohol abuse, alcohol consumption, alcohol dehydrogenase, Alcohol Drinking, alcohol intoxication, alcohol metabolism, Alcohol-Related Disorders, Aldehyde Dehydrogenase, article, Biopsy, Needle, cancer risk, carcinogen, carcinogenesis, cell damage, cell differentiation, cell proliferation, colorectal cancer, cytochrome P450, Disease mechanisms, DNA damage, DNA synthesis, Female, folic acid, gastrointestinal disease, Gastrointestinal diseases, Gastrointestinal Neoplasms, hemoglobin, hepatitis C, high risk behavior, human, Humans, immune response, immunohistochemistry, incidence, lipoprotein, liver cancer, liver tumor, male, Middle Aged, molecular interaction, Neoplasms, nonhuman, oropharynx cancer, oxidation kinetics, pathophysiology, priority journal, reactive oxygen metabolite, risk factor, Severity of Illness Index, Sex Distribution, Survival Rate, Switzerland, systematic review, tubulin
Abstract
Background/Aims: Alcohol drinking is responsible for a number of gastrointestinal diseases and cancers. Although heavy drinking episodes and chronic drinking are well linked to mechanisms of disease, moderate alcohol consumption and its effects are less well known. This review attempts to fill a gap in the literature surrounding moderate alcohol consumption. Methods: A systematic review of the English literature using PubMed was used. Results: A dose-response risk relationship exists between alcohol consumption and digestive disease risk. Acetaldehyde is the main factor in alcohol-related damage in moderate alcohol consumption and acts through numerous methods to exert damaging effects. Conclusion: Zero alcohol intake is recommended for lowest risk of alcohol-related digestive tract diseases and conditions. However, given the lowest overall mortality is associated with moderate drinking, moderate drinking with no bingeing episodes is recommended. Copyright