Search resultsThe effect of moderate alcohol consumption on bone mineral density: A study of female twins
Title
The effect of moderate alcohol consumption on bone mineral density: A study of female twins
Publication type
Journal Article
Year of Publication
2005
Authors
Journal
Annals of the Rheumatic Diseases
Volume
64
Issue
2
Pagination
309 - 310
Date published
2005
ISBN
00034967 (ISSN)
Keywords
alcohol consumption, Alcohol Drinking, alkaline phosphatase, alkaline phosphatase blood level, article, bone density, bone metabolism, bone turnover, cigarette smoking, confidence interval, controlled study, drinking behavior, Ethanol, Female, fracture, genetic analysis, hip, Hip Joint, hormone, hormone substitution, human, Humans, lumbar spine, Lumbar Vertebrae, major clinical study, menopausal syndrome, monozygotic twins, Osteocalcin, priority journal, questionnaire, risk assessment, Twins, Monozygotic
Abstract
Background: Osteoporosis is associated with morbidity and mortality, particularly in postmenopausal women. The effect of moderate alcohol intake on bone mineral density (BMD) and fracture risk remains unclear. Objective: To carry out a twin study to investigate this effect while controlling for genetic effects and other confounding variables. Methods: BMD was determined at the hip and lumbar spine in 46 pairs of monozygotic twins discordant for alcohol consumption. Biochemical evidence of altered bone metabolism was sought. Results: A positive association between alcohol consumption and BMD was shown, in contrast to the negative effect of smoking on BMD. Markers of bone turnover were not associated with alcohol or BMD. Conclusions: Moderate alcohol consumption is not harmful to bone health in women and may even be beneficial. Beneficial effects do not appear to be mediated through an action on bone metabolism.