Search resultsA prospective study linked both alcohol and tobacco to Dupuytren's disease
Title
A prospective study linked both alcohol and tobacco to Dupuytren's disease
Publication type
Journal Article
Year of Publication
2004
Authors
Journal
Journal of Clinical Epidemiology
Volume
57
Issue
8
Pagination
858 - 863
Date published
2004
ISBN
08954356 (ISSN)
Keywords
Adult, age distribution, Aged, Aged, 80 and over, alcohol consumption, Alcohol Drinking, article, cohort analysis, controlled study, Denmark, Dose-Response Relationship, Drug, Dupuytren contracture, Dupuytren's Contracture, Dupuytren's disease, Epidemiologic Methods, Ethanol, Female, follow up, human, Humans, Life Style, major clinical study, male, Middle Aged, multivariate logistic regression analysis, priority journal, risk assessment, risk factor, self report, Sex Distribution, smoking, statistical analysis, tobacco, tobacco use
Abstract
Objective To address the role of alcohol intake and tobacco smoking and the combination of the two on subsequent risk of Dupuytren's disease. Study design and setting Cohort study of 7,254 subjects enrolled in the Copenhagen City Heart Study (1981-1983). Both self-reported information on lifestyle and objective measures at the baseline examination were linked to presence of Dupuytren's disease at a subsequent examination (1991-1994) using multivariate logistic regression analysis. Results A total of 772 subjects had signs of Dupuytren's disease at follow-up. After adjustment for age, sex, educational level, diabetes, and either alcohol or tobacco consumption, respectively, odds ratios for having the disease increased in a dose-dependent manner with increasing levels of alcohol or tobacco intake; however, there was no statistical interaction between heavy smoking and heavy drinking. Conclusion Alcohol intake and tobacco smoking are independently associated with increased risk of Dupuytren's disease, and the combination of the two conveys a very large risk.