Search resultsImpact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotype
Title
Impact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotype
Publication type
Journal Article
Year of Publication
2002
Authors
Journal
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume
22
Issue
5
Pagination
824 - 831
Date published
2002
ISBN
10795642 (ISSN)
Keywords
Adolescent, Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, apolipoprotein A1, apolipoprotein B, apolipoprotein E, Apolipoprotein E polymorphism, Apolipoproteins E, article, atherosclerosis, body mass, Body Mass Index, Cardiovascular Diseases, cardiovascular risk, Cholesterol, cholesterol blood level, cigarette smoking, Context dependency, controlled study, disease association, Female, gender, genetic variability, genotype, Health Surveys, high density lipoprotein cholesterol, human, Humans, hyperlipidemia, lipid metabolism, Lipids, lipoprotein blood level, Lipoproteins, low density lipoprotein cholesterol, major clinical study, male, Middle Aged, Polymorphism, Genetic, prediction, priority journal, Quebec, risk assessment, Risk Factors, sex difference, Sex Factors, smoking
Abstract
Hyperlipidemia, smoking, and obesity are well-known risk factors for cardiovascular disease. Conversely, moderate alcohol intake is associated with lower atherosclerosis risk. However, the influence of taking alcohol on the interrelationships of these factors in a particular context has not been thoroughly investigated. In this study, we asked whether the association between plasma measures of lipid metabolism and alcohol intake is dependent on context defined by gender, age, body mass index (BMI), smoking, and apolipoprotein E (APOE) genotype. Data were obtained in a sample of 869 women and 824 men who participated in the Quebec Heart Health Survey. There was no evidence that variation among APOE genotypes influenced the association between LDL cholesterol (LDL-C) or HDL cholesterol (HDL)-C and alcohol, after adjustment for age and BMI. Further, the positive (LDL-C and BMI) and the negative (HDL-C and BMI) associations that were observed in men and women with the ε3/2 and ε3/3 genotypes were not modified by alcohol intake. However, in women with the ε4/3 genotype only, we found a significant influence of an alcohol by BMI interaction on the prediction of total cholesterol, LDL-C, HDL-C, apoA-I, and apoB, and this interaction was influenced by the status of smoking. Whereas the influence of an alcohol by BMI interaction on total cholesterol and LDL-C was significant in smokers, its influence on HDL-C was significant only in non-smokers. This study emphasizes the context dependency of the influence of alcohol on lipid metabolism and demonstrates how biological, environmental, and genetic factors interact to determine cardiovascular disease risk.