Search resultsCocarcinogenic effects of alcohol in hepatocarcinogenesis
Title
Cocarcinogenic effects of alcohol in hepatocarcinogenesis
Publication type
Journal Article
Year of Publication
2002
Authors
Journal
Gut
Volume
51
Issue
1
Pagination
132 - 139
Date published
2002
ISBN
00175749 (ISSN)
Keywords
acetaldehyde, alcohol, alcohol consumption, alcohol metabolism, alcoholic beverage, Animals, cancer incidence, carcinogenicity, Carcinogens, Carcinoma, Hepatocellular, cocarcinogenesis, cytokine release, Cytokines, diet, disease association, environmental factor, Environmental Pollutants, enzyme activation, epidemiological data, Ethanol, Hepatitis, Hepatitis virus, human, Humans, immune response, Immune Tolerance, infection sensitivity, Liver, liver carcinogenesis, liver cell carcinoma, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, Liver Neoplasms, methylation, nonhuman, pathophysiology, precancer, Precancerous Conditions, priority journal, Retinoids, review, signal transduction
Abstract
Alcohol is a major aetiological factor in hepatocarcinogenesis but our understanding of its importance as a modulating factor is just beginning to emerge. In the present review, a number of possible cofactors and mechanisms are discussed by which alcohol may enhance the development of hepatoma. These include dietary or environmental carcinogens ingested along with alcoholic beverages, alcoholic cirrhosis as a precancerous condition, and the effects of alcohol metabolism.