Search resultsGenetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels
Title
Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels
Publication type
Journal Article
Year of Publication
2002
Authors
Journal
Atherosclerosis
Volume
164
Issue
1
Pagination
171 - 177
Date published
2002
ISBN
00219150 (ISSN)
Keywords
Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, Aldehyde Dehydrogenase, Aldehyde dehydrogenase 2, aldehyde dehydrogenase isoenzyme 2, ALDH2 protein, human, article, blood, body mass, Cholesterol, cholesterol blood level, Cholesterol, HDL, cigarette smoking, controlled study, coronary artery disease, daily life activity, drinking behavior, electrocardiogram, Female, genetic polymorphism, genetic variability, genetics, genotype, hemoglobin A1c, hemoglobin determination, high density lipoprotein, high density lipoprotein cholesterol, High-density lipoprotein, homozygosity, human, Humans, Japan, Lipoproteins, HDL Cholesterol, major clinical study, male, metabolism, Middle age, Middle Aged, polymerase chain reaction, Polymorphism, Polymorphism (Genetics), Polymorphism, Genetic, priority journal, Support, Non-U.S. Gov't, total cholesterol
Abstract
Moderate drinkers with a defective alcohol dehydrogenase type 3 (ADH3) genotype have higher high-density lipoprotein (HDL) levels and a decreased risk of coronary artery disease (CAD). We examined the interaction between the aldehyde dehydrogenase type 2 (ALDH2), alcohol intake, and HDL levels in 826 men and 1295 women in a rural town in Japan. The ALDH2 genotype of each subject was determined by polymerase chain reaction (PCR) analysis. HDL was adjusted for the alcohol intake, age, body mass index, smoking status, total cholesterol, triglycerides and HbA1c levels. None of the subjects had a history or ECG suggestive of CAD. The proportions of ALDH2, *1/*1, *1/*2, and *2/*2 (defective homozygote) were 45.8, 46.0, and 8.2%, respectively, for men. Drinking more than two drinks daily was associated with lower HDL levels in men with the defective genotypes compared with men with a normal genotype (55.6±0.9 vs. 51.2±0.9 mg/dl, mean±S.E., P<0.0001). Also, drinking more than 0.5 drinks daily was not associated with beneficial effects on HDL levels in women with defective ALDH2 genotypes. Conclusions: Alcohol intake did not have beneficial effects on HDL levels in the defective ALDH2 genotype and may not protect against CAD in subjects with defective ALDH2 genotypes.