Search resultsIsocitrate and lactate dehydrogenase activities in human blood serum after a single, moderate dose of various alcoholic beverages
Title
Isocitrate and lactate dehydrogenase activities in human blood serum after a single, moderate dose of various alcoholic beverages
Publication type
Journal Article
Year of Publication
2000
Authors
Journal
Z Zagadnien Nauk Sadowych
Volume
41
Pagination
27 - 36
Date published
2000
ISBN
12307483 (ISSN)
Keywords
acetaldehyde, Adult, alcohol, alcohol blood level, alcohol consumption, Alcoholemia, Alcoholic Beverages, article, calorimetry, controlled study, drug elimination, enzyme activity, enzyme blood level, human, human experiment, isocitrate dehydrogenase, Isocitrate dehydrogenase (ICDH), lactate dehydrogenase, Lactate dehydrogenase (LDH), liver cell membrane, male, Serum levels
Abstract
The studies were performed on 12 healthy men who were given ethanol (first vodka, then wine and finally beer) in a single, oral dose of 0.84 g/kg b.w. The activities of both dehydrogenases were determined by calorimetric methods in serum collected prior to alcohol administration and when its blood level ≤ 0.1‰. During the experiment, the blood levels of ethanol and total acetaldehyde were examined. As we expected, alcohol resulted in a statistically significant increase in enzyme activities (except for isocitrate dehydrogenase after beer). Considering the remaining results, the authors conclude that an increase in serum lactate dehydrogenase may result from the impaired function of the hepatocyte membrane, while an increase in isocitrate dehydrogenase depends on the ethanol elimination rate.