Search resultsSmoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: A population-based cohort study
Title
Smoking and alcohol intake as risk factors for bleeding and perforated peptic ulcers: A population-based cohort study
Publication type
Journal Article
Year of Publication
2000
Authors
Journal
Epidemiology
Volume
11
Issue
4
Pagination
434 - 439
Date published
2000
ISBN
10443983 (ISSN)
Keywords
Adult, Aged, Aged, 80 and over, alcohol consumption, Alcohol Drinking, Alcoholic Beverages, article, bleeding, cigarette smoking, cohort analysis, Cohort Studies, Cohort study, drinking behavior, Female, hospitalization, human, Humans, incidence, major clinical study, male, Middle Aged, Peptic Ulcer, Peptic ulcer hemorrhage, Peptic ulcer perforation, population research, priority journal, Regression Analysis, Risk Factors, smoking, stomach acid secretion, ulcer perforation
Abstract
Both the incidence of and mortality from bleeding and perforated peptic ulcers are increasing. We assessed the association between smoking, intake of alcohol (including type of alcoholic beverage), and risk of a complicated peptic ulcer in a population-based study of 26,518 Danish subjects followed up for an average of 13.4 years. There were 214 cases of incident bleeding and 107 cases with perforated ulcers. We estimated relative risks (RRs) for incident bleeding and perforated peptic ulcers using Poisson regression analysis. Smoking more than 15 cigarettes per day compared with never smoking increased the risk of a perforated ulcer more than threefold [RR = 3.5; 95% confidence interval (CI) = 1.7-7.1)]. Drinking more than 42 drinks per week increased the risk of a bleeding ulcer fourfold (RR = 4.4; 95% CI = 2.3-8.3) compared with drinking less than one drink per week. Using the same comparison group, subjects who drank more than 21 drinks per week but no wine were at a higher risk of a bleeding ulcer (RR = 8.8; 95% CI = 2.2-35) than drinkers of the same amount of alcohol, but with more than 25% of their intake as wine (RR = 2.4; 95% CI = 1.0-6.0).