Search resultsAlcohol consumption had no beneficial effect on serum lipids in a substantial proportion of patients with primary hyperlipidemia
Title
Alcohol consumption had no beneficial effect on serum lipids in a substantial proportion of patients with primary hyperlipidemia
Publication type
Journal Article
Year of Publication
2000
Authors
Journal
Journal of Clinical Epidemiology
Volume
53
Issue
10
Pagination
1020 - 1024
Date published
2000
ISBN
08954356 (ISSN)
Keywords
Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, article, Chi-Square Distribution, cholesterol blood level, cigarette smoking, Cross-Sectional Studies, cross-sectional study, Female, heart protection, high density lipoprotein, high density lipoprotein cholesterol, High-density lipoprotein, human, Hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, Linear Models, lipid, lipid blood level, lipid metabolism, Lipoproteins, HDL Cholesterol, major clinical study, male, Middle age, Primary hyperlipidemia, priority journal, Risk Factors, smoking, triacylglycerol, triacylglycerol blood level
Abstract
The cardioprotective effect of moderate alcohol consumption, which is mediated largely by an elevation of high-density lipoprotein (HDL) levels, may be absent in patients with primary disorders of lipid metabolism. In 881 untreated, unrelated patients with primary hyperlipidemia, we estimated the effect of alcohol on fasting serum HDL cholesterol concentration adjusted for age, gender, diet, and smoking with a multiple linear regression model. The number of abstainers, moderate users (1-30 g daily), and heavy alcohol consumers (≥30 g daily) was not different between three types of hyperlipidemia. Among hypercholesterolemic (n = 514) and combined hyperlipidemic (n = 227) patients, consumers of alcohol had higher HDL levels compared to abstainers (P(for trend) = 0.0001 and 0.0002, respectively). Heavy drinkers with combined hyperlipidemia had higher triglyceride levels compared to moderate drinkers and abstainers (P(for trend) = 0.008). Alcohol consumption had no effect on the lipid profiles in 140 patients with hypertriglyceridemia. In conclusion, combined hyperlipidemic and hypertriglyceridemic patients may profit from an encouragement to stop consuming alcohol. On the other hand, moderate use of alcohol may delay the development of coronary artery disease in hypercholesterolemic patients by an elevation of HDL levels. (C) 2000 Elsevier Science Inc.