Search resultsMetabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides the Atherosclerosis Risk in Communities (ARIC) study
Title
Metabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides the Atherosclerosis Risk in Communities (ARIC) study
Publication type
Journal Article
Year of Publication
2001
Authors
Journal
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume
21
Issue
2
Pagination
275 - 281
Date published
2001
ISBN
10795642 (ISSN)
Keywords
Adult, Aged, alcohol consumption, article, atherosclerosis, Carotid Arteries, Carotid Artery Diseases, Chylomicrons, Diet, Atherogenic, Dietary Fats, disease association, Fasting, Female, human, Humans, hyperlipidemia, Life Style, lifestyle, lipid blood level, Lipids, Lipoproteins, major clinical study, male, Middle Aged, Postprandial, Postprandial Period, postprandial state, priority journal, risk factor, Risk Factors, smoking, triacylglycerol blood level, Triglycerides, Tunica Intima
Abstract
Despite the reported association of lipoprotein responses to a fatty meal with atherosclerosis, little is known about the determinants of these responses. Plasma triglyceride, retinyl palmitate, and apolipoprotein B-48 responses to a standardized fatty meal containing a vitamin A marker were measured in 602 Atherosclerosis Risk in Communities (ARIC) study participants. To focus on postprandial responses specifically, which have been reported to be related to atherosclerosis independently of fasting triglycerides, analyses for determinants of postprandial responses were adjusted for fasting triglycerides. Major determinants of fasting triglycerides, namely, diabetes, obesity, other factors related to insulin resistance, and male sex, were not independently associated with postprandial responses. Fasting triglycerides were the strongest predictor of postprandial lipids, but independent of triglycerides, the predictors of postprandial responses were smoking, diet, creatinine, and alcohol. Smokers had substantially increased retinyl palmitate and apolipoprotein B-48 responses, indicators of chylomicrons and their remnants. Persons who consume more calories or ω3 fatty acids had reduced chylomicron responses. Triglyceride responses were associated positively with serum creatinine levels and negatively with moderate alcohol consumption. Thus, determinants of fasting and postprandial lipids differ. The independent atherogenic influence of postprandial lipids may relate more to smoking and diet than to obesity and insulin resistance.