Search resultsDeterminants of sex hormone-binding globulin in normal postmenopausal women
Title
Determinants of sex hormone-binding globulin in normal postmenopausal women
Publication type
Journal Article
Year of Publication
2001
Authors
Journal
Clinical Endocrinology
Volume
54
Issue
1
Pagination
81 - 87
Date published
2001
ISBN
03000664 (ISSN)
Keywords
absorptiometry, Adult, Aged, alcohol consumption, Alcohol Drinking, anamnesis, article, Blood Glucose, body composition, body weight, cardiovascular disease, Cross-Sectional Studies, dietary intake, Estradiol, estradiol blood level, Exercise, Female, glucose, glucose blood level, Glucose Tolerance Test, human, human experiment, Humans, insulin, insulin blood level, Insulin-Like Growth Factor I, Middle Aged, normal human, obesity, osteoporosis, physical activity, postmenopause, priority journal, protein blood level, Regression Analysis, sex hormone binding globulin, Sex Hormone-Binding Globulin, smoking
Abstract
OBJECTIVE. To examine the factors influencing the levels of sex hormone-binding globulin (SHBG) in normal postmenopausal women by assessing the relationship between SHBG and measured anthropometric, metabolic and hormonal variables. DESIGN. Cross-sectional, observational study. SUBJECTS and METHODS: Seventy normal postmenopausal women aged 47-71 years (mean 58 years), participated in the study. Information was collected on medical, reproductive and smoking history, alcohol use, dietary intake and physical activity. Body composition measurements using dual-energy absorptiometry, and analyses of biochemical and hormonal indices were performed. RESULTS. Bivariate correlation coefficients indicated that SHBG was inversely related to body weight (r = -0.44), fat mass (r = - 0.35), and abdominal obesity (r = - 0.42). It was also inversely related to the glucose and insulin levels during an oral glucose tolerance test (-0.24 < r < -0.40), serum oestradiol (r = - 0.26), and physical activity (r = - 0.24). Multiple regression analysis indicated that significant independent correlates of SHBG concentration were fat mass, physical activity, alcohol intake, serum oestradiol, and insulin-like growth factor-1, all having a negative impact on SHBG. CONCLUSIONS. From these observed associations, it is concluded that maintenance of body weight, moderate alcohol consumption, and physical activity will tend to reduce SHBG concentrations in postmenopausal women, thereby increasing the levels of free oestradiol. This mechanism could mediate the beneficial effects of these factors in preventing the development of osteoporosis and cardiovascular disease.