Search resultsLifestyle factors and plasma homocysteine concentrations in a general population sample
Title
Lifestyle factors and plasma homocysteine concentrations in a general population sample
Publication type
Journal Article
Year of Publication
2001
Authors
Journal
American Journal of Epidemiology
Volume
154
Issue
2
Pagination
150 - 154
Date published
2001
ISBN
00029262 (ISSN)
Keywords
Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, amino acid blood level, Analysis of Variance, article, cardiovascular disease, Cardiovascular Diseases, cardiovascular risk, coffee, controlled study, Cross-Sectional Studies, diet, Diet Surveys, disease association, Exercise, Female, folic acid, homocysteine, human, Humans, hyperhomocysteinemia, Life Style, lifestyle, Linear Models, male, Middle Aged, Multivariate Analysis, Netherlands, population research, Questionnaires, Sampling Studies, smoking, tea, Vitamin B Complex, vitamin B group
Abstract
The authors cross-sectionally investigated the extent to which coffee, tea, and alcohol consumption, physical activity, and smoking were associated with nonfasting total plasma homocysteine concentrations in a random sample of 3,025 Dutch adults aged 20-65 years from a population-based cohort examined in 1993-1996 (n = 19,066), The lifestyle factors most strongly associated with plasma total homocysteine level were smoking (positive), alcohol drinking (negative), and coffee consumption (positive). The smoking effect was most prominent in women, and the alcohol effect was most pronounced in men. Data indicated that independently of other lifestyle factors, age, and intake of folate and B vitamin supplements, a change in lifestyle could result in a 0.1- to 1.7-μmol/liter change in plasma total homocysteine level. The authors conclude that lifestyle changes could result in a public-health-relevant change in plasma total homocysteine concentrations.