Search resultsCigarette smoking, alcohol consumption and risk of systemic lupus erythematosus
Title
Cigarette smoking, alcohol consumption and risk of systemic lupus erythematosus
Publication type
Journal Article
Year of Publication
2014
Authors
Journal
Lupus
Volume
23
Issue
6
Pagination
537 - 544
Date published
2014
ISBN
09612033 (ISSN)
Keywords
alcohol, alcohol consumption, Alcohol Drinking, article, autoantibody, autoimmunity, cigarette smoke, disease activity, disease severity, DNA adduct, DNA damage, double stranded DNA antibody, drinking behavior, Environmental Exposure, environmental factor, genetic predisposition, Genetic Predisposition to Disease, genetics, genotype environment interaction, granulocyte macrophage colony stimulating factor, human, Humans, immunoglobulin G antibody, Immunology, innate immunity, interleukin 1, interleukin 6, interleukin 8, Lupus Erythematosus, Systemic, meta analysis (topic), pathogenesis, priority journal, protection, Protective factors, risk assessment, risk factor, Risk Factors, skin lupus erythematosus, smoking, systemic lupus erythematosus, tumor necrosis factor alpha
Abstract
Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease whose pathogenesis is thought to involve both genetic and environmental factors. It is possible that common environmental exposures, such as cigarette smoking and alcohol consumption, might modify risk of disease development in certain individuals. Here we aim to review the epidemiologic evidence related to the association of cigarette smoking, alcohol consumption and the risk of developing SLE. A growing body of evidence suggests that cigarette smoking confers a short-term increased risk of SLE in genetically susceptible individuals. On the other hand, alcohol consumption in moderate doses may have a protective effect against the development of SLE, although this is still debated. We also have reviewed proposed mechanistic explanations underlying the role of cigarette smoking and alcohol consumption in SLE pathogenesis.