Search resultsModerate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women
Title
Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women
Publication type
Journal Article
Year of Publication
2012
Authors
Journal
Menopause
Volume
19
Issue
9
Pagination
974 - 979
Date published
2012
ISBN
10723714 (ISSN)
Keywords
Absorptiometry, Photon, Adult, alcohol, alcohol abstinence, alcohol consumption, Alcohol Drinking, alcohol withdrawal, article, biological marker, Biological Markers, bone density, Bone Remodeling, bone turnover, C-terminal telopeptide, carboxy terminal telopeptide, Collagen Type I, controlled study, correlational study, dual energy X ray absorptiometry, Dual-energy X-ray absorptiometry, Estradiol, Ethanol, Female, human, Humans, Immunoassay, Middle Aged, ossification, Osteocalcin, osteolysis, osteoporosis, Osteoporosis, Postmenopausal, Peptides, postmenopause, Serum estradiol
Abstract
Objective: Epidemiological studies indicate that higher bone mass is associated with moderate alcohol consumption in postmenopausal women. However, the underlying cellular mechanisms responsible for the putative beneficial effects of alcohol on bone are unknown. Excessive bone turnover, combined with an imbalance whereby bone resorption exceeds bone formation, is the principal cause of postmenopausal bone loss. This study investigated the hypothesis that moderate alcohol intake attenuates bone turnover after menopause. METHODS: Bone mineral density was determined by dual-energy X-ray absorptiometry in 40 healthy postmenopausal women (mean ± SE age, 56.3 ± 0.5 y) who consumed alcohol at 19 ± 1 g/day. Serum levels of the bone formation marker osteocalcin and the resorption marker C-terminal telopeptide (CTx) were measured by immunoassay at baseline (day 0) and after alcohol withdrawal for 14 days. Participants then consumed alcohol and were assayed on the following morning. RESULTS: Bone mineral density at the trochanter and total hip were positively correlated to the level of alcohol consumption. Serum osteocalcin and CTx increased after abstinence (4.1 ± 1.6%, P = 0.01 and 5.8 ± 2.6%, P = 0.02 compared with baseline, respectively). Osteocalcin and CTx decreased after alcohol readministration, compared with the previous day (-3.4 ± 1.4%, P = 0.01 and-3.5 ± 2.1%, P = 0.05, respectively), to values that did not differ from baseline (P > 0.05). Conclusions: Abstinence from alcohol results in increased markers of bone turnover, whereas resumption of alcohol reduces bone turnover markers. These results suggest a cellular mechanism for the increased bone density observed in postmenopausal moderate alcohol consumers. Specifically, the inhibitory effect of alcohol on bone turnover attenuates the detrimental skeletal consequences of excessive bone turnover associated with menopause.