Search resultsThe effect of alcohol on postprandial and fasting triglycerides
Title
The effect of alcohol on postprandial and fasting triglycerides
Publication type
Journal Article
Year of Publication
2012
Authors
Journal
International Journal of Vascular Medicine
Volume
2012
Date published
2012
ISBN
20902824 (ISSN)
Keywords
Adipose Tissue, alcohol, alcohol consumption, chylomicron, disease association, enzyme activity, human, hypertriglyceridemia, lipid diet, lipoprotein lipase, lipoprotein synthesis, liver metabolism, nonhuman, postprandial state, review, saturated fatty acid, triacylglycerol, very low density lipoprotein
Abstract
Alcohol has a significant additive effect on the postprandial triglyceride peak when it accompanies a meal containing fat, especially saturated fat. This results from a decrease in the breakdown of chylomicrons and VLDL remnants due to an acute inhibitory effect of alcohol on lipoprotein lipase activity. Furthermore, alcohol increases the synthesis of large VLDL particles in the liver, which is the main source of triglycerides in the hypertriglyceridemia associated with chronic excessive alcohol intake. In case of chronic consumption, lipoprotein lipase activity seems to adapt itself. The effect of alcohol on adipose tissues is less clear. Sometimes, a severe hypertriglyceridemia induced by alcohol (SHIBA) can be observed, especially in patients with type 2 diabetes mellitus and/or obesity increasing the risk of pancreatitis.