Search resultsLiver Cancer and Alcohol
Title
Liver Cancer and Alcohol
Publication type
Journal Article
Year of Publication
2012
Authors
Journal
Clinics in Liver Disease
Volume
16
Issue
4
Pagination
839 - 850
Date published
2012
ISBN
10893261 (ISSN)
Keywords
aflatoxin B1, alcohol, alcohol abuse, alcohol consumption, Alcohol Drinking, alcohol liver cirrhosis, alcohol liver disease, Alcoholism, alpha fetoprotein, cancer growth, cancer risk, carcinogen, Carcinoma, Hepatocellular, computer assisted tomography, Diabetes Complications, diabetes mellitus, DNA damage, drinking behavior, echography, Ethanol, fatty liver, Female, gene expression, hepatitis B, Hepatitis B, Chronic, hepatitis C, Hepatitis C virus, Hepatitis C, Chronic, human, Humans, incidence, iron overload, liver cancer, liver cell carcinoma, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, liver disease, Liver Diseases, liver injury, Liver Neoplasms, liver transplantation, male, Metabolic Networks and Pathways, metabolic syndrome X, obesity, outcome assessment, pathogenesis, review, risk factor, Risk Factors, sensitivity and specificity, smoking, tobacco, ultrasound, United States, virus hepatitis
Abstract
Annually, hepatocellular carcinoma is diagnosed in approximately a half-million people worldwide. Based on the association of alcohol with cancer, a International Agency for Research on Cancer working group recently deemed alcoholic beverages "carcinogenic to humans," causally related to occurrence of malignant tumors of the oral cavity, pharynx, larynx, esophagus, liver, colorectum, and female breast. Alcohol metabolism in the liver leads to reactive oxygen species production, induction of activity of cytochrome P450s, and reduction of antioxidants. This review analyzes the epidemiology and pathogenesis of alcohol in hepatocellular cancer.