Search resultsThe 1258 G>A polymorphism in the neuropeptide Y gene is associated with greater alcohol consumption in a Mediterranean population
Title
The 1258 G>A polymorphism in the neuropeptide Y gene is associated with greater alcohol consumption in a Mediterranean population
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
Alcohol
Volume
45
Issue
2
Pagination
131 - 136
Date published
2011
ISBN
07418329 (ISSN)
Keywords
Adult, alcohol consumption, Alcohol Drinking, anxiety, article, controlled study, exon, Female, gene frequency, gene sequence, genetic association, genetic polymorphism, genetic variability, genotype, homozygosity, human, Humans, lifestyle, male, Mediterranean Region, Middle Aged, neuropeptide Y, nucleic acid analysis, nucleotide sequence, Polymorphism, Single Nucleotide, Population Groups, sequence analysis, sex difference, single nucleotide polymorphism, Spain
Abstract
Neuropeptide Y (NPY) is a neurotransmitter widely distributed in the central nervous system. Several studies have demonstrated that increases of NPY are associated with reduced alcohol intake and anxiety manifestations. The Leu7Pro polymorphism in the NPY has been associated with alcohol consumption, but evidence is scarce. In the Spanish Mediterranean population, this variant is not polymorphic. Thus, our aim is to identify novel functional variants in the NPY and to investigate the impact of these markers and others previously described on alcohol consumption in this population. A total of 911 subjects (321 men and 590 women) from the Spanish Mediterranean population were recruited. Alcohol consumption, and demographic and lifestyle variables were measured. Nucleotide sequence determination and SNP analyses were carried out. Only one exonic SNP was detected by direct sequencing (1258 G>A or rs9785023; allele frequency 0.47). From the intronic markers chosen (483 A>G or rs13235938, 2517 A>G or rs4722342, and 7065 A>G or rs4722343), only the two latter ones were polymorphic (allele frequencies 0.46 and 0.04, respectively), and none of them were associated with alcohol consumption. However, the 1258 G>A SNP was associated (recessive pattern) with higher alcohol intake. This association was particularly relevant in men with high alcohol intake (59.1 ± 5.0 g/day in AA as opposed to 40.6 ± 7.5 in the G carriers, P= .022) and women with moderate alcohol intake (7.3 ± 5.5. g/day in AA as opposed to 4.6 ± 3.9. g/day in G carriers, P= .048). The 1258 G>A polymorphism in the NPY is associated with higher alcohol consumption in the Mediterranean population.