Search resultsHealthy Brain Aging: Effect of Head Injury, Alcohol and Environmental Toxins
Title
Healthy Brain Aging: Effect of Head Injury, Alcohol and Environmental Toxins
Publication type
Journal Article
Year of Publication
2010
Authors
Journal
Clinics in Geriatric Medicine
Volume
26
Issue
1
Pagination
29 - 44
Date published
2010
ISBN
07490690 (ISSN)
Keywords
aging, alcohol, alcohol consumption, Alcohol-Related Disorders, Alzheimer's disease, apolipoprotein E, Brain, brain function, Brain Injuries, carcinogen, clinical trial, cognition, Cognition Disorders, cognitive defect, Cognitive dysfunction, confusion, dementia, diffusion tensor imaging, disease association, Environmental Exposure, gene frequency, genetic polymorphism, glutathione transferase, head injury, human, Humans, mental health, meta analysis, neurofibrillary tangle, neuropsychological test, Noxae, nuclear magnetic resonance imaging, oxidative stress, Parkinson disease, pathogenesis, polymerase chain reaction, protein processing, psychomotor performance, review, risk assessment, risk reduction, systematic review, Toxins, Biological, traumatic brain injury
Abstract
Head injury has been recognized as an increasingly important determinant of late-life cognitive function. Despite a large number of research and clinical studies, no direct link has been established between minor head trauma with or without loss of consciousness and the development of dementia of the Alzheimer type. Similarly for alcohol, low doses have been found to be somewhat protective against dementia, whereas large doses increased the risk of late-life cognitive dysfunction. Among the many environmental toxins suspected of causing cognitive dysfunction, lead intoxication has the strongest evidence to support a link.