Search resultsPre-diagnostic alcohol consumption and breast cancer recurrence and mortality: Results from a prospective cohort with a wide range of variation in alcohol intake
Title
Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: Results from a prospective cohort with a wide range of variation in alcohol intake
Publication type
Journal Article
Year of Publication
2013
Authors
Journal
International Journal of Cancer
Volume
132
Issue
3
Pagination
686 - 694
Date published
2013
ISBN
00207136 (ISSN)
Keywords
Adult, Aged, alcohol, alcohol consumption, Alcohol Drinking, antineoplastic agent, article, breast cancer, Breast Neoplasms, cancer diagnosis, cancer mortality, cancer recurrence, cancer risk, cohort analysis, Cohort Studies, controlled study, Female, follow up, high risk patient, human, human tissue, Humans, Life Style, lifestyle, major clinical study, Middle Aged, mortality, Neoplasm Recurrence, Local, priority journal, Prognosis, Prospective Studies, prospective study, Recurrence, risk assessment, risk factor, Risk Factors, socioeconomics, tumor characteristics
Abstract
The association between pre-diagnostic alcohol consumption and breast cancer recurrence and breast cancer specific mortality was investigated in 1,052 women diagnosed with early breast cancer in a prospective cohort of 29,875 women. Known clinical, lifestyle and socioeconomic risk factors were evaluated and adjusted for in multivariate analysis. We found a modest but significant association between pre-diagnostic alcohol consumption and breast cancer recurrence with a median follow-up of six years after date of diagnosis, both when using baseline measures of alcohol intake (HR, 1.65; 95% CI, 1.02-2.67; >2 units/day vs. ≤1 unit/day) and cumulated alcohol intake (HR, 2.02; 95% CI, 1.06-3.85; >40 drinking years vs. 0