Search resultsAdiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction: Health check-up study of Japanese men
Title
Adiponectin negatively correlates with alcoholic and non-alcoholic liver dysfunction: Health check-up study of Japanese men
Publication type
Journal Article
Year of Publication
2013
Authors
Journal
Hepatology Research
Volume
43
Issue
3
Pagination
238 - 248
Date published
2013
ISBN
13866346 (ISSN)
Keywords
adiponectin, Adult, alanine aminotransferase, alanine aminotransferase blood level, alcohol consumption, article, Central obesity, controlled study, cross-sectional study, disease association, enzyme blood level, fatty liver, human, hypoadiponectinemia, insulin resistance, Japanese, Liver dysfunction, liver enzyme, major clinical study, male, medical examination, nonalcoholic fatty liver, obesity, priority journal, protein blood level, waist circumference
Abstract
Aim: Central obesity, insulin resistance and alcohol consumption are thought to be major risk factors for fatty liver formation. Adiponectin (APN) prevents fatty liver formation, and its serum levels are lower in subjects with central obesity and/or insulin resistance. The aim of this study was to explore the association among serum APN levels, central obesity, insulin resistance and liver dysfunction with or without fatty liver classified by alcohol consumption in healthy subjects. Methods: A total of 5588 Japanese male subjects who underwent a health check-up were classified into three groups according to alcohol consumption: non- or light drinkers (15g/day≥ethanol); mild drinkers (15g/day