Search resultsModerate, excessive or heavy alcohol consumption: Each is significantly associated with increased mortality in patients with chronic hepatitis C
Title
Moderate, excessive or heavy alcohol consumption: Each is significantly associated with increased mortality in patients with chronic hepatitis C
Publication type
Journal Article
Year of Publication
2013
Authors
Journal
Alimentary Pharmacology and Therapeutics
Volume
37
Issue
7
Pagination
703 - 709
Date published
2013
ISBN
02692813 (ISSN)
Keywords
Adult, Aged, alcohol consumption, Alcohol Drinking, article, Cardiovascular Diseases, cardiovascular mortality, cause of death, Cohort Studies, controlled study, disease association, drinking behavior, Female, follow up, hepatitis C, Hepatitis C, Chronic, high risk population, human, Humans, liver disease, major clinical study, male, Middle Aged, mortality, Multivariate Analysis, Nutrition Surveys, outcome assessment, priority journal, Proportional Hazards Models, Questionnaires, risk assessment, Risk Factors, United States, Young Adult
Abstract
Summary Background The impact of moderate alcohol consumption on long-term outcomes of chronic hepatitis C (CH-C) infected patients remains controversial. Aim To assess the impact of moderate alcohol consumption on long-term outcomes of CH-C patients using population-based data. Methods Data were obtained from the Third National Health and Nutrition Examination Survey (NHANES III)-mortality linked files. Alcohol consumption was estimated as grams/day. Multivariate Cox proportional hazards model was utilized to assess the effects of CH-C and alcohol consumption on mortality (all causes, cardiovascular disease, and liver disease). Results A total of 8985 participants were included as the study cohort. Of these, 218 had CH-C. The follow-up time was 162.95 months for CH-C and 178.27 months for controls. CH-C patients had increased risk for both overall mortality and liver-related mortality. CH-C patients with excessive alcohol consumption had even higher risks for overall mortality and liver-related mortality. The risk of overall mortality associated with CH-C increased with moderate alcohol consumption of 1-19 g/day and heavy alcohol consumption ≥30 g/day. Conclusion Although chronic hepatitis C is associated with increased risks for overall and liver-related mortality, these risks are even higher for patients consuming moderate and excessive amounts of alcohol.