Search resultsRetrobulbar blood flow and visual field alterations after acute ethanol ingestion
Title
Retrobulbar blood flow and visual field alterations after acute ethanol ingestion
Publication type
Journal Article
Year of Publication
2013
Authors
Journal
Clinical Ophthalmology
Volume
7
Pagination
1641 - 1646
Date published
2013
ISBN
11775467 (ISSN)
Keywords
Adult, alcohol, alcohol blood level, alcohol consumption, article, Blood Flow Velocity, blood pressure, color ultrasound flowmetry, diastolic blood pressure, end diastolic velocity, eye blood flow, Female, Frequency doubling perimetry, giant cell, heart rate, hemodynamic parameters, human, human experiment, imaging system, intracellular signaling, intraocular pressure, male, normal human, ophthalmic artery, peak systolic velocity, perimetry, prospective study, retina artery, Retrobulbar blood flow, Short-wavelength automated perimetry, systolic blood pressure, Visual field, visual field defect, visual system
Abstract
Background: The purpose of this study was to test the effect of ethyl alcohol on the koniocellular and magnocellular pathway of visual function and to investigate the relationship between such visual field changes and retrobulbar blood flow in healthy subjects. Methods: In 12 healthy subjects (mean age 32 ± 4 years), color Doppler imaging, short-wavelength automated perimetry, and frequency doubling perimetry was performed before and 60 minutes after oral intake of 80 mL of 40 vol% ethanol. Mean and pattern standard deviations for short-wavelength automated and frequency doubling perimetry were assessed. End diastolic velocity (EDV) and peak systolic velocity (PSV) were measured in the central retinal and ophthalmic arteries using color Doppler imaging. Systemic blood pressure, heart rate, intraocular pressure, and blood alcohol concentration were determined. Results: Mean PSV and EDV in the central retinal artery showed a significant increase after alcohol intake (P = 0.03 and P = 0.02, respectively). Similarly, we found a significant acceleration of blood flow velocity in the ophthalmic artery (P = 0.02 for PSV; P = 0.04 for EDV). Mean intraocular pressure decreased by 1.0 mmHg after alcohol ingestion (P = 0.01). Retinal sensitivity in short-wavelength automated perimetry did not alter, whereas in frequency doubling perimetry, the mean deviation decreased significantly. Systolic and diastolic blood pressure did not change significantly. Mean blood alcohol concentration was 0.38 ± 0.16 g/L. Conclusion: Although ethanol is known to cause peripheral vasodilation, our subjects had no significant drop in systemic blood pressure. However, a significant increase of blood flow velocity was seen in the retrobulbar vessels. Regarding visual function, moderate alcohol consumption led to reduced performance in the magnocellular visual system tested by frequency doubling perimetry, but had no effect on short-wavelength automated perimetry.