Search resultsA lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fatto modulate serum hdl-cholesterol concentrations
Title
A lipoprotein lipase gene polymorphism interacts with consumption of alcohol and unsaturated fatto modulate serum hdl-cholesterol concentrations
Publication type
Journal Article
Year of Publication
2013
Authors
Journal
Journal of Nutrition
Volume
143
Issue
10
Pagination
1618 - 1625
Date published
2013
ISBN
00223166 (ISSN)
Keywords
Adult, Aged, alcohol consumption, Alcohol Drinking, allele, Alleles, article, Asian Continental Ancestry Group, body mass, Body Mass Index, body weight, caloric intake, carbohydrate intake, cholesterol blood level, Cholesterol, HDL, cohort analysis, controlled study, correlation coefficient, diet, Dietary Fats, dietary intake, DNA polymorphism, Ethanol, Fatty Acids, Unsaturated, Female, follow up, food composition, gene linkage disequilibrium, genetic association, Genome-Wide Association Study, genotype, high density lipoprotein cholesterol, human, Humans, hypertriglyceridemia, lifestyle, Linkage Disequilibrium, lipoprotein lipase, major clinical study, male, medical history, metabolic equivalent, Middle Aged, Mutation, mutational analysis, obesity, physical activity, Polymorphism, Genetic, polyunsaturated fatty acid, Prospective Studies, protein interaction, questionnaire, Republic of Korea, smoking, triacylglycerol, Triglycerides, unsaturated fatty acid
Abstract
There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk. Our prospective cohort study investigated the interactive effects of a common LPL polymorphism and lifestyle factors, including obesity, smoking, alcohol consumption, physical activity, and dietary intake, on follow-up measurements of HDL-C and triglyceride (TG) concentrations. A total of 5314 Korean men and women aged 40-69 y participated in the study. Serum HDL-C and TG concentrations were measured in all participants at baseline and 6-y follow-up examinations. On the basis of genomewide association data for HDL-C and TG concentrations, we selected the most significant polymorphism (rs10503669), which was in high linkage disequilibrium with the serine 447 stop (S447×) mutation (D'= 0.99) of LPL. We found that carrying the T allele reflecting the LPL 3447 allele was positively associated with follow-up measurement of HDL-C concentrations (P < 0.001). In the linear regression model adjusted for baseline HDL-C concentration and potential risk factors, we observed interactive effects of the polymorphism and consumption of alcohol (P-interaction < 0.01) and unsaturated fat (P-interaction < 0.05) on follow-up measurement of HDL-C concentrations. We also observed interactive effects of the polymorphism and body mass index (P-interaction < 0.01) on follow-up measurement of TG concentrations after adjusting for the baseline level and potential risk factors. Our findings suggest that carriers of the LPL×447 allele benefit frommoderate alcohol consumption and a diet high in unsaturated fat to minimize reduction of blood HDL-C concentrations and that obese persons who do not carry the LPL × 447 allele need to control body weight to prevent hypertriglyceridemia.