Search resultsGenome-wide association studies identify genetic loci related to alcohol consumption in Korean men
Title
Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
American Journal of Clinical Nutrition
Volume
93
Issue
4
Pagination
809 - 816
Date published
2011
ISBN
00029165 (ISSN)
Keywords
2' 5' oligoadenylate synthetase 3 gene, Adult, Aged, alcohol consumption, Alcohol Drinking, Aldehyde Dehydrogenase, aldehyde dehydrogenase 2 gene, allele, article, Asian Continental Ancestry Group, chromosome 12 open reading frame 51 gene, chromosome 12q, Chromosomes, Human, Pair 12, cohort analysis, Cohort Studies, coiled coil domain containing 63 gene, controlled study, cut like homeobox 2 gene, DNA, gene, gene locus, Genetic Loci, genetic trait, Genome-Wide Association Study, genotype, human, Humans, Introns, Korea, Linear Models, Linkage Disequilibrium, major clinical study, male, Middle Aged, Polymorphism, Single Nucleotide, rabphilin 3a homolog gene, rural area, single nucleotide polymorphism, urban area, Urban Population, ventricular regulatory myosin light chain gene
Abstract
Background: Genome-wide association (GWA) studies regarding the quantitative trait of alcohol consumption are limited. Objective: The objective of the study was to explore genetic loci associated with the amount of alcohol consumed. Design: We conducted a GWA study with discovery data on single nucleotide polymorphisms (SNPs) for 1721 Korean male drinkers aged 40-69 y who were included in an urban population-based cohort. Another sample that comprised 1113 male drinkers who were from an independent cohort enrolled in a rural area served as a resource for replication. At baseline (18 June 2001 through 29 January 2003), members of both cohorts provided information on average daily alcohol consumptions, and their DNA samples were collected for genotyping. Results: We tested 315,914 SNPs of discovery data by using multivariate linear regression analysis adjusted for age and smoking, and 12 SNPs on chromosome 12q24 had genome-wide significant associations with alcohol consumption; adjusted P values by using Bonferroni correction were 1.6 × 10 -5 through 5.8 × 10-46. We observed most SNPs in intronic regions and showed that the genes that harbor SNPs were C12orf51, CCDC63, MYL2, OAS3, CUX2, and RPH3A. In particular, signals in or near C12orf51, CCDC63, and MYL2 were successfully replicated in the test for 317,951 SNPs; rs2074356 in C12orf51 was in high linkage disequilibrium with SNPs in ALDH2, but other SNPs were not. Conclusions: In a GWA study, we identified loci and alleles highly associated with alcohol consumption. The findings suggest the need for further investigations on the genetic propensity for drinking excessive amounts of alcohol.