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Title

Potential role of the alcohol and smoking in the squamous cell carcinoma of the head and neck: Review of the current literature and new perspectives

Publication type

Journal Article

Year of Publication

2011

Authors

Zygogianni, A., Kyrgias, G., Mystakidou, K., Antypas, C., Kouvaris, J., Papadimitriou, C., Armonis, V., Alkati, H., Kouloulias, V.

Journal

Asian Pacific Journal of Cancer Prevention

Volume

Issue

Pagination

339 - 344

Date published

2011

ISBN

15137368 (ISSN)

Keywords

alcohol consumption, Alcohol Drinking, cancer, Carcinoma, Squamous Cell, drinking behavior, Factor interactions, Head and neck, Head and Neck Neoplasms, head and neck tumor, human, Humans, risk factor, Risk Factors, short survey, smoking, squamous cell carcinoma, Tobacco smoking

Abstract

Alcohol and tobacco are responsible for a very large proportion of chronic disease and some tumors in particular may be the result of interactions between the two risk factors. The present systematic literature review was conducted to judge combined effects of alcohol drinking and tobacco, as well as and genetic polymorphisms on alcohol-related cancer risk. We can conclude that the interaction of smoking and alcohol significantly increases the risk for aero-digestive cancers. Unfortunately, little is known about mechanisms and details of interaction with regard to disease outcomes, which is why particular questions must be targeted in future research efforts.

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