Search resultsAlcohol consumption at midlife and successful ageing in women: A prospective cohort analysis in the nurses' health study
Title
Alcohol consumption at midlife and successful ageing in women: A prospective cohort analysis in the nurses' health study
Publication type
Journal Article
Year of Publication
2011
Authors
Journal
PLoS Medicine
Volume
8
Issue
9
Date published
2011
ISBN
15491277 (ISSN)
Keywords
Adult, age, Aged, aging, alcohol consumption, Alcohol Drinking, article, Chronic Disease, cognitive defect, cohort analysis, controlled study, developmental stage, drinking behavior, Female, food frequency questionnaire, health status, human, Humans, mental disease, Middle Aged, midlife, nurse, nurse attitude, Nurses, nursing research, Odds Ratio, physical disease, physiology, Prospective Studies, prospective study, Risk, risk assessment, statistics, survival time, United States, women's health
Abstract
Background: Observational studies have documented inverse associations between moderate alcohol consumption and risk of premature death. It is largely unknown whether moderate alcohol intake is also associated with overall health and well-being among populations who have survived to older age. In this study, we prospectively examined alcohol use assessed at midlife in relation to successful ageing in a cohort of US women. Methods and Findings: Alcohol consumption at midlife was assessed using a validated food frequency questionnaire. Subsequently, successful ageing was defined in 13,894 Nurses' Health Study participants who survived to age 70 or older, and whose health status was continuously updated. "Successful ageing" was considered as being free of 11 major chronic diseases and having no major cognitive impairment, physical impairment, or mental health limitations. Analyses were restricted to the 98.1% of participants who were not heavier drinkers (<45 g/d) at midlife. Of all eligible study participants, 1,491 (10.7%) achieved successful ageing. After multivariable adjustment of potential confounders, light-to-moderate alcohol consumption at midlife was associated with modestly increased odds of successful ageing. The odds ratios (95% confidence interval) were 1.0 (referent) for nondrinkers, 1.11 (0.96-1.29) for ≤5.0 g/d, 1.19 (1.01-1.40) for 5.1-15.0 g/d, 1.28 (1.03-1.58) for 15.1-30.0 g/d, and 1.24 (0.87-1.76) for 30.1-45.0 g/d. Meanwhile, independent of total alcohol intake, participants who drank alcohol at regular patterns throughout the week, rather than on a single occasion, had somewhat better odds of successful ageing; for example, the odds ratios (95% confidence interval) were 1.29 (1.01-1.64) and 1.47 (1.14-1.90) for those drinking 3-4 days and 5-7 days per week in comparison with nondrinkers, respectively, whereas the odds ratio was 1.10 (0.94-1.30) for those drinking only 1-2 days per week. Conclusions: These data suggest that regular, moderate consumption of alcohol at midlife may be related to a modest increase in overall health status among women who survive to older ages. Please see later in the article for the Editors' Summary.